- Producer27/04/2017The Importance Of Supporting Scientific Research: A Personal StorySome years ago, while attending graduate school at Binghamton University, I had the incredible good fortune of completing a doctoral dissertation under the mentorship of Dr. Linda Spear. I was also lucky enough to have the companionship of...
- 23/04/2017Update on Basketball Therapy for Parkinson's Disease This is Dr Gary Sharpe, it is the 25th March 2017. I will try everything I can to escape my prison of Parkinson's Disease. I will never accept the...
- 22/04/2017β-caryophylleneCopaiba Oil-Resin Treatment Is Neuroprotective and Reduces Neutrophil Recruitment and Microglia Activation after Motor Cortex Excitotoxic Injurywww.hindawi.com Evidence-Based Complementary and Alternative Medicine (eCAM) is an international peer-reviewed, Open Access journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and...
Comments25/04/2017 #3 Gerald Hecht#2 @Ian Weinberg plus it's high in Omega-3; I'll try anything that helps me feel that all the world's a sunny day, etc.
Oh ...and the accompanying mantra: "''tis more rewarding to give 'buried intradermal sutures' --than to have to lie around, having just received them...ommm".22/04/2017 #2 Ian Weinberg#1 Thanks for the share @Gerald Hecht Yes, indeed. Interesting, encouraging. But then the ravages of the inflammatory process are the low level chronicity. Need to build on this in terms of the longer term maintenance treatment in the chronic disorders - Alzheimer's etc. But yes, a possible angle here. Thanks again, and may the Force be with you!
- 21/04/2017WHOOPS --DARPA's AT IT AGAIN...Brain Stimulation Restores Memory During Lapseswp.me Researchers report direct brain stimulation could help improve memory...
Comments21/04/2017 #4 Gerald Hecht#2 @Jan 🐝 Barbosa FWIW...back in the sixties/early seventies --no one in my "neck o' the woods knew what ADHD was ...so I was just labeled "182 IQ gifted serial juvenile delinquent" --then later they put me on meds and I finished an award winning Ph.D. Dissertation and NIDA postdoc within a few years...than later:1) I had my job illegally taken from me and 2) commenced legal proceedings until my funds ran out ...3) there are still so scared they still keep my name in the catalog to "draw" students, paid me for two years to not come in and work.
1) 2) and 3) (above) would not have been possible if I hadn't STOPPED my meds and LET MY FREAK ADHD FLAG FLY!!!21/04/2017 #3 Gerald Hecht#1 @Joyce 🐝 Bowen Brand Ambassador @ beBee I know a bit about MS...much of that via a nonlinear...nonverbal "thingie" with my best friend when I was working on my Master's at WCU; as she says: "never say never"...if I challenge her...her (as of last month "useless-demyelinated motor neuron innervated") triceps bring her fist --or worse...fist holding a cane or other heavy object down...hard on my head; she then tells me that ice and direct pressure are best (and to try not to fall asleep until I'm confident that I haven't a subdural hematoma) and that she has to return to her busy practice as a medical psychologist.
My only solace is that the variant she was DX'd with is chronic, progressive, nonremitting...and that she doesn't believe stuff that people tell her by default. She also doesn't pay people who tell her stuff (in a professional capacity) that she doesn't like21/04/2017 #2 Jan 🐝 BarbosaMy Inattentive ADD is quite bothering... Its something I can live with... but nevertheless ive lost brain power, before I could recite more than 150 quotes... not let alone 10... plus my lack of focus has kept me form reading.... Its became worst about when I hit 38... Now im pushing my brain to read and write... ADD Pills give some concentration at the expense of my heart wanting to burst out of my chest !!!
- 14/04/2017It's gotta scale --if you wanna wail...Human Cognitive Map Scales According to Surroundingswp.me A new study investigates how we are able to assess new locations and become orientated with the help of visual...
- Producer03/04/2017The Surprising Things That Can Cause Breakouts Most people suffer from acne at some point in their lives. Acne is caused by a number of factors, such as genetics and how oily your skin is, but there are some surprising things that contribute to acne that are often overlooked. The following are...
- 05/05/2016Sandrine Thuret: You can grow new brain cells. Here's how | TED Talk | TED.comwww.ted.com Can we, as adults, grow new neurons? Neuroscientist Sandrine Thuret says that we can, and she offers research and practical advice on how we can help our brains better perform neurogenesis—improving mood, increasing memory formation and preventing...
- 28/03/2017RESEARCH REVIEW OF A YEAR OF OUT-THINKING PARKINSON'S
Not Just Neurology
I am now convinced more than ever that the help I was provided by a holistic wellness coach @Deb 🐝 Helfrich, which set me on the path to Out-Thinking Parkinson's, was exactly the kind of help I needed ... that we all need. My year of researching PD very broadly, and my documented recovery based on this, has shown me that it is very far from just a case of "brain rot"... instead PD is a systemic set of issues, including gut, mental health, stress, physical and emotional injuries and traumas, inflammatory factors, nutritional deficits and genetics. I now know for certain that neurology does not hold all the answers to PD, and, indeed people affected by the disease all over the world and being failed by healthcare systems which consider it just a Speciality of Brain Doctor's!
I also now buy utterly into my coach's messages of the fact that, when it comes to our own health, "You are the Expert in You", and the need to Unlearn our Learned Helplessness in this regard.How Can I Start to Help my Friend with Parkinson's Disease?www.outthinkingparkinsons.com When someone with Parkinson's comes into your life, you have a lot of catching up to do. The point of this article is to open up your eyes to ways that you can start with what you know and begin to offer some support to someone who has a...
- 28/03/2017Reflections of a Year of Out-Thinking Parkinson's via a Video Diary. Part 13: 22nd March 2016Mirroring Games for Movement Recovery in Parkinson's Disease Hi, this is Gary Sharpe. It is the 22nd of March 2016. In this video I want to talk about mirroring. Now, it’s well known that doing things like dance...
Comments28/03/2017 #1 Gerald HechtWell as you know, back when I conducted the (now famous --I'm getting old, lol) "First Ecologically Valid Animal Model Of Prenatal Cocaine Exposure" ...this was a tremendously difficult/important problem; https://drive.google.com/open?id=0B9GW-p_btMtha2tPWGI3SlUyU2s
until fairly recently, most medication development (pre clinical and early clinical) was conducted on males ALMOST EXCLUSIVELY...the tremendously complex biochemical interactions with female neuroendocrine cyclicity was...well I was told to "not attempt this study" because of the issue!
- 27/03/2017I don't know if this has any diagnostic value or not --but when I look at the guy who invented the famous Rorschach "inkblot test" --I SEE BRAD PITT!
Comments28/03/2017 #6 Gerald Hecht#5 @Yogesh Sukal I would say that you have made a very wise choice...sometimes I have to drive through it (well around it); and even that seems like it could turn into an X-Files episode
http://new.dhh.louisiana.gov/index.cfm/directory/detail/21927/03/2017 #2 Gerald Hecht#1 @Yogesh Sukal hopefully I'm not the only one...because there are two places where nobody can hear you scream: 1) outer space, and 2) The Psychiatric Hospital in Jackson Louisiana (listen to the Johnny and June Carter Cash record "Going to Jackson for details)
https://youtu.be/43qK1Lh2xH027/03/2017 #1 Yogesh SukalLol 😂😂😂
In that case, I don't know what psychologist will have conclusions about your thinking or perhaps it may change their perception about Rorschach test and only winner will be perception. :)
Which is the basis for this test , perception from perceptions from the test which is questionable in many people perceptions.
Anyone have any perception about my this perception?
- 23/03/2017Things aren't always what they seem...i.e., an apparent overlap of a "health care issue" AND a "foreign policy issue"...may in fact be something that trumps both.Selank - Wikipediaen.m.wikipedia.org
- 22/03/2017Dateline: March 21, 2017.
FDA approval granted for a newer MAO-B Inhibitor as an adjunct medication (to increase "on time" interval temporal length)...theoretically resulting in less time in dyskinetic "off time".FDA Approves New Parkinson's Disease Treatmentwww.empr.com Data showed Xadago statistically and significantly...
Comments23/03/2017 #3 Gerald Hecht#2 @Lisa Vanderburg I also find it interesting that many MAO-B Specific Inhibitors exhibit TNF-alpha antagonist/anti pro inflammatory cytokine effects...
...the location of the heaviest "investment" in researching this issue also (quite probably) "trumps politics":
✨💫🌈🕶22/03/2017 #1 Gerald HechtWell, the pharmacodynamic concept (related to MAO-B SELECTIVE Inhibition) can be traced to:
Selegiline which was discovered by Z. Ecseri at the Hungarian drug company, Chinoin (part of Sanofi since 1993), which they called E-250.
Chinoin received a patent on the drug in the early 1960’s and a research monograph and related pre clinical journal articles first appeared in the scientific literature in English in 1965 (or ‘66) if memory serves.
Work on the biochemistry and effects of E-250 in animals and humans was led by a group headed by József Knoll who is given credit with bringing it to market under the trade name L-Deprenyl. That is a “fascinating” story in and of itself...best saved for another day.
- 22/03/20174-biomarker signature may improve risk prediction and diagnostics for the management of cardiovascular diseaseJCI - Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaqueswww.jci.org
- Producer15/03/2017The problem with GusThis is the story of Gus. Gus like all of us was once a dependent infant. He required feeds, security and love. Unfortunately there were times when Gus’s needs weren’t promptly met. With the dropping of his blood sugar levels and the delay in...
Comments23/04/2017 #38 Joyce 🐝 Bowen Brand Ambassador @ beBeeDr. Spock was said to have expressed that he created a generation of monsters. I read him religiously before and after the birth of my first. Did he coin the term partial reinforcement? I deliberately waited to fulfill the needs of my first. My second was born with hyaline membrane disease with a subsequent collapsed lung and I sprung into action each time he cried. What a difference between my two guys that exists even today.30/03/2017 #37 Gerald Hecht#33 yea...you know @Brian McKenzie even society's "machinations"... like "the legal system" ...just a way for society to slap it self on the back and tell itself: "we done good"...and the individuals who fall for it until its too late...fortunately, I was able to bear witness to the machine --as it was given the assignment of providing a remedy for its own affirmative action based rationale for violating the due process rights of myself (in the role of the individual)... I got to see its uselessness from the "best front row seats in the house".
Now, finally, I can truly say..."I know some stuff"!16/03/2017 #35 Ken BoddieLove the psycho-physiological theme, Ian, and the sound advice. A seriously entertaining read with a meaningful moral. So ..... just to tick all the boxes, we should stop spitting the dummy, avoid the one finger rule, think outside the square, and stop acting like a bunch of trolls?. Easy peasy! Got it!
Now pardon me for asking, but what's in it for me?
Sorry, mate, just applying some tensile force to your lower extremity. 🤣16/03/2017 #33 Brian McKenzie#27 @Gerald Hecht I have no inclination nor motivation to save 'society' - I am quite content to throw gas on the embers to help its destruction any way I can. $ociety is the enemy of the individual - it nearly always has been. How many iterations of "If you dont follow our (often arbitrary & capricious) imposed rules you will be fined, tortured, cast out, imprisoned, excommunicated or executed" do you need to show this as true?15/03/2017 #31 Liesbeth Leysen, MSc. Brand Ambassador beBee, Inc.Love the way you brought it @Ian Weinberg, a good reminder!15/03/2017 #30 Sara JacoboviciThanks for the tag @Ian Weinberg. You have Gus down pact and I am encouraged to see that there is a Charlie and all the other variables because that's what keeps things so interesting. When we work backwards, we can see the route a Gus has taken. But it's the variables, those who had the same outset but took different turns, who help us marvel at what it means to be human. I would be worried if I heard you say that you have nailed it after x number of years. No matter how predictable we are, there is always someone who can still surprise us.15/03/2017 #28 Ian Weinberg#23 Why not @Gerald. BTW, in my actual program the Gus's are referred to as Bravo's and those that never experienced any meaningful response to their needs emerged as 'Charlies' - low self-esteem, hopeless-helpless with raging levels of pro-inflammatory cytokines. All the variables that you mention are indeed relevant - but where to start? I've been profiling now for 25 years and still haven't nailed it. I'm aiming for some posthumous recognition ...15/03/2017 #27 Gerald HechtWait...what if @Brian McKenzie cottoned on to the critical variable straight away...imagination! That would be cool! Some people better than others at keeping themselves amused under conditions of deprivation...from the "outside", it would look like "a high tolerance for deprivation" and a desire to put society's needs ahead of one's own: "Self-sacrifice"!
Society benefiting from the behavior of an individual who is clueless to the fact that they are putting the needs of society ahead of their own.
That would be something...15/03/2017 #26 Harvey Lloyd#15 I agree with the devoid of feeling area but even intellectually you walk away wondering what happened. I went for the therapy but decided against it as I had decorated and installed a tv. So i was fairly comfortable. once you become inverted the following applies. If you are not the lead dog the view never changes.
- 14/03/2017IT'S THE DENDRITES SILLY!Brain could be 10 times more active than scientists thoughtwww.cbsnews.com Research from UCLA could challenge scientists’ conception of how the brain...
Comments14/03/2017 #3 Gerald Hecht#2 @Devesh 🐝 Bhatt Exactly! It always has been; funny (but true) s tory...shortly after Albert Einstein moved to Princeton, he was at a party; and after having "a few too many"... he remarked that several members of the administration seemed to be people who "only used 10% of their brains."
Because it was Einstein who said it...many people (fellow professors!!!) assumed that it was true and that he was being serious, LOL.
Anyway that is the actual origin of that saying...I can't tell you how many Psychology Professors and Neuroscience Professors have ACTUALLY TAUGHT THAT IN CLASS (and believed it)...a whole generation or three of "educated people" have grown up...actually believing this to be a "primary rule" in PSYCHOLOGY/NEUROSCIENCE!!!
It's always been known by serious scientists to be untrue (just think of REM sleep as one piece of evidence)...any electrophysiologist working in the CNS knows that we ALWAYS use ALL of our brain...ALL OF THE TIME...
These "new' details about the dynamics of dendritic "resting potential fluctuations" just helps to explain a little bit more about the mechanism...gets closer the quantum world of subatomic particle physics.
Pretty cool stuff!!
- 13/03/2017Clinical Trial For Cerebral Aneurysm Appears To Still Be OpenSafety and Efficacy Study of Etanercept for Aneurysmal Subarachnoid Hemorrhage - Full Text View - ClinicalTrials.govclinicaltrials.gov
- 13/03/2017APPEARS TO STILL BE RECRUITING PARTICIPANTS FOR CLINICAL INTERVENTION OF CEREBRAL ANEURYSM:
--Another Type of Paradigm Shiftwww.bebee.com Traditionally, students have been introduced to the study of Pharmacology by dividing the subject into two broad subfields; 1) Pharmacokinetics :...
- 04/03/2017Break Glass OBLY in Case of Emergency!Dr. Gerald S. Hechtpsiwebsubr.org
- 04/03/2017You guessed it --another "RES IPSA LOQUITUR!"Big Pharma Quietly Enlists Leading Professors to Justify $1,000-Per-Day Drugswww.propublica.org As it readies for battle with President Trump over drug prices, the pharmaceutical industry is deploying economists and health care experts from the nation’s top universities. In scholarly articles, blogs and conferences, they lend their prestige to...
- 03/03/2017RES IPSA LOQUITUR!Medicinal plants - Wikipediaen.m.wikipedia.org
- 02/03/2017Ketamine Eases Severe Depression, But Questions of Dosage and Duration Remainwp.me Summary: A new study reports research into the term of use of ketamine to treat depression is limited.Source: Yale.Recent studies have confirmed observations made by Yale clinicians decades...
- 27/02/2017What Is Perispinal Administration?Another Kind OF Paradigm Shiftplus.google.com Another Kind OF Paradigm Shift - Gerald Hecht -...
- Producer25/02/2017Buzzing with emotionThis article has been updated with the insertion of instructional video clips. This may enhance the value of the subject specifically as regards psychotherapists, coaches and those interested in the current understanding of the mind-body...
Comments27/03/2017 #24 Gerald Hecht#23 @Ian Weinberg oh yeah...that would explain the darkness, phone charger malfunction and lack of A.C.
although, the sunset was magnificent; I guess that tomorrow I should pop in and see the friendly folks at the Utility Company...my cat doesn't like it when it's real humid and hot...somehow, I've become more of an Acadian than she is...and she was born here.
I was sent here from Nova Scotia by the British...but...I'm a Levee builder; it's in my blood.26/03/2017 #20 Savvy RajAppreciate your field of work on the neuromodulators as well the insights @Ian Weinberg and thank you for providing some clarity on a very challenging subject. Mental health issues are certainly tough on the sufferer and their support system like their family and friends. Your post is informative and interesting as well. Kudos for creating such a succint awareness of the dance of opposition in the inverse interplay of these emotion centers.26/03/2017 #18 Gerald Hechthey @Ian Weinberg , have you noticed how many botanical sources of naturally occurring MAO-B selective Inhibitors there are; and how many of them also have anti pro-inflammatory cytokine activity as well? I wonder if its a coincidence that even the "laboratory/kitchen made" ones also do the 5-HT2c/empathogen thingie? I wonder if its a coincidence that the substituted phenylethlamine "DOI" is not only the most potent TNF-alpha inhibitor known to humankind...but also provides a long "day at the beach trip", was first synthesized and documented by Sasha (Shulgin)...and how long and "zany/happy" --the lives of folks like Sasha and Albert Hoffman are best characterized as...
...personally, I prefer "zany/happy/whacky/silly" to umm... whatever the opposite of that is...and also prolly explains why its taking me so long to get into one coherent book (I don't want it to be non-linear/heavily annotated in the David Foster Wallace sense --cause there is no need for that with the "mainstreaming" of what we used to call hypertext...
...its more the case that actually writing it is less fun than doing it, lol.
I should listen to my inner @Phil Friedman and "measure twice, cut once"...actually, I guess that's what I'm doing...Mahalo!26/03/2017 #15 Sara JacoboviciGrateful for the tag @Ian Weinberg. Love your work and I find that you're a great communicator; both written and as a speaker (plus, I appreciate your sense of humour). "The quietening of the amygdala", great title for a future work. You write, "Unfortunately for us, the amygdala is in turn stimulated by the very chemicals that it secretes." For me, this is a reminder that the strides we have made in looking at our brain is great, but at the same time, we are still at the mercy of its mysteries. Looking forward to future posts.26/03/2017 #14 CityVP 🐝 ManjitPrior to reading this I would be clueless if someone had said "Nucleus Accumbens". This is nothing like the social press that the Amygdala has received and perhaps I don't know it because nucleus accumbens isn't something that jumps of the page, but I can for sure see the relationship between the two now and it makes me wonder how these part of the brain triggered each other in the brain of David Foster Wallace - a great writer who succumbed to the malady of depression.
I will follow up more on this part of the brain, thank you for elevating my understanding Ian.
http://www.neuroscientificallychallenged.com/blog/2014/6/11/know-your-brain-nucleus-accumbens26/03/2017 #13 Joyce 🐝 Bowen Brand Ambassador @ beBeeVery interesting. I have never been able to take SSRIs, always suspecting my dopamine and norephinerinwhatcahwhosit levels needed to be played with. There are, however, few medications that I found to do this. Now that I'm aging, side effects are critical. I experience quick and severe elevations in blood pressure, so there are many medications I can't take. Gabapentin has been successful in alleviating what I'll call the 'trapped animal' syndrome.
Of course, I am just an amateur. You provide a wonderful path to understanding some of it.26/02/2017 #10 Ian Weinberg#6 Apologies @Pamela 🐝 Williams I seem to have digressed and missed the important point that you raised: Yes absolutely. The presence of your father may well have created a stressed, high cortisol milieu in your pregnant mom which may have sensitized the amygdala of the unborn fetus. The introvertedness which subsequently developed in the child/adult could well reflect a heritage of fear and defensiveness. Thanks again for that shared info.
Comments25/02/2017 #54 Liesbeth Leysen, MSc. Brand Ambassador beBee, Inc.@Jeremy 🐝 Krier you are an awesome Bee.25/02/2017 #53 Liesbeth Leysen, MSc. Brand Ambassador beBee, Inc.Oh my God what a beautiful gift thanks so much