- 27/03/2017I don't know if this has any diagnostic value or not --but when I look at the guy who invented the famous Rorschach "inkblot test" --I SEE BRAD PITT!
- 23/03/2017Things aren't always what they seem...i.e., an apparent overlap of a "health care issue" AND a "foreign policy issue"...may in fact be something that trumps both.Selank - Wikipediaen.m.wikipedia.org
- 22/03/2017Dateline: March 21, 2017.
FDA approval granted for a newer MAO-B Inhibitor as an adjunct medication (to increase "on time" interval temporal length)...theoretically resulting in less time in dyskinetic "off time".FDA Approves New Parkinson's Disease Treatmentwww.empr.com Data showed Xadago statistically and significantly...
Comments23/03/2017 #3 Gerald Hecht#2 @Lisa Vanderburg I also find it interesting that many MAO-B Specific Inhibitors exhibit TNF-alpha antagonist/anti pro inflammatory cytokine effects...
...the location of the heaviest "investment" in researching this issue also (quite probably) "trumps politics":
✨💫🌈🕶22/03/2017 #1 Gerald HechtWell, the pharmacodynamic concept (related to MAO-B SELECTIVE Inhibition) can be traced to:
Selegiline which was discovered by Z. Ecseri at the Hungarian drug company, Chinoin (part of Sanofi since 1993), which they called E-250.
Chinoin received a patent on the drug in the early 1960’s and a research monograph and related pre clinical journal articles first appeared in the scientific literature in English in 1965 (or ‘66) if memory serves.
Work on the biochemistry and effects of E-250 in animals and humans was led by a group headed by József Knoll who is given credit with bringing it to market under the trade name L-Deprenyl. That is a “fascinating” story in and of itself...best saved for another day.
- 22/03/20174-biomarker signature may improve risk prediction and diagnostics for the management of cardiovascular diseaseJCI - Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaqueswww.jci.org
- Producer15/03/2017The problem with GusThis is the story of Gus. Gus like all of us was once a dependent infant. He required feeds, security and love. Unfortunately there were times when Gus’s needs weren’t promptly met. With the dropping of his blood sugar levels and the delay in...
Comments16/03/2017 #35 Ken BoddieLove the psycho-physiological theme, Ian, and the sound advice. A seriously entertaining read with a meaningful moral. So ..... just to tick all the boxes, we should stop spitting the dummy, avoid the one finger rule, think outside the square, and stop acting like a bunch of trolls?. Easy peasy! Got it!
Now pardon me for asking, but what's in it for me?
Sorry, mate, just applying some tensile force to your lower extremity. 🤣16/03/2017 #33 Brian McKenzie#27 @Gerald Hecht I have no inclination nor motivation to save 'society' - I am quite content to throw gas on the embers to help its destruction any way I can. $ociety is the enemy of the individual - it nearly always has been. How many iterations of "If you dont follow our (often arbitrary & capricious) imposed rules you will be fined, tortured, cast out, imprisoned, excommunicated or executed" do you need to show this as true?15/03/2017 #31 Liesbeth Leysen, MSc. Brand Ambassador beBee, Inc.Love the way you brought it @Ian Weinberg, a good reminder!15/03/2017 #30 Sara JacoboviciThanks for the tag @Ian Weinberg. You have Gus down pact and I am encouraged to see that there is a Charlie and all the other variables because that's what keeps things so interesting. When we work backwards, we can see the route a Gus has taken. But it's the variables, those who had the same outset but took different turns, who help us marvel at what it means to be human. I would be worried if I heard you say that you have nailed it after x number of years. No matter how predictable we are, there is always someone who can still surprise us.15/03/2017 #28 Ian Weinberg#23 Why not @Gerald. BTW, in my actual program the Gus's are referred to as Bravo's and those that never experienced any meaningful response to their needs emerged as 'Charlies' - low self-esteem, hopeless-helpless with raging levels of pro-inflammatory cytokines. All the variables that you mention are indeed relevant - but where to start? I've been profiling now for 25 years and still haven't nailed it. I'm aiming for some posthumous recognition ...15/03/2017 #27 Gerald HechtWait...what if @Brian McKenzie cottoned on to the critical variable straight away...imagination! That would be cool! Some people better than others at keeping themselves amused under conditions of deprivation...from the "outside", it would look like "a high tolerance for deprivation" and a desire to put society's needs ahead of one's own: "Self-sacrifice"!
Society benefiting from the behavior of an individual who is clueless to the fact that they are putting the needs of society ahead of their own.
That would be something...15/03/2017 #26 Harvey Lloyd#15 I agree with the devoid of feeling area but even intellectually you walk away wondering what happened. I went for the therapy but decided against it as I had decorated and installed a tv. So i was fairly comfortable. once you become inverted the following applies. If you are not the lead dog the view never changes.15/03/2017 #25 Emilia M. LudovinoThanks @Ian Weinberg for tagging me, otherwise I'd miss this excellent write-up of "Gus a Narcissist in the making" :). I fully agree with you that by "growing ourselves we will grow the greater collective". Though the challenge is to be self-aware of our inner Gus and also be aware of the nefarious Gus(es) in the collective and know how to safely deal with them. @Gert 🐝 Scholtz how interesting that you bring the attachment styles to the conversation, as I personally think that insecure attachment is characterized by a greater degree of narcissistic vulnerability.15/03/2017 #23 Gerald HechtBrilliant Ian! Of course, (like all of your stuff) it is spawing questions at an alarming rate --some, just silly, and some serious and possibly testable;
a silly one would be that usually that expression about a male counterpoint to "Debbie Downer" is often called a "Gloomy Gus"...but this Gus can't afford that action (until his premature death).
A testable one might be something like: Given that we start out in with the same limited repertoire as Gus...why are some of us more "Guslike" than others?
We can only guess and test...one possible answer is an "uncomfortable" one; namely that having relatively "inattentive" or "emotionally absent" caregivers could , in the long run be "good for society" (Gus' Amygdala is conditioned from the get go to "wait it out".
Alternatively, there could be individual differences in how we develop "deal with it" tactics.
Also Alternatively, there may be innate (as in genetic) differences in reward sensitivity...like a disease model of addiction.
It could be a number of other things as well.
We should start work right away, I'll send you my a'lol15/03/2017 #17 Gerald Hecht#1 @Brian McKenzie maybe hundreds! Who knows? Imagination is probably key...and acting ability; and openly carrying firearms...wait; how about building a global business empire with an absolutely breathtaking facade (include a crappy plastic casino in New Jersey and then name it : "The Taj Mahal"...
...No... I got it! Become a King in America under one's own name...wait; okay; I got it: become THE FIRST KING in America --under one's own name! (unless you have a name like Gus)...then just go with the family name and hope that it also works as a word indicating that you are holding a "special" card in a casino game.
The card, which when played, results in a reward-mediated release of dopamine accompanied by an Oxytocin boost!15/03/2017 #16 Ian Weinberg#13 @Deb 🐝 Helfrich Perhaps things can only change for Gus when either they feel too stressed about being Gus or when they've destroyed too many relationships and reach a lonely hopeless-helpless space. I've also found that a physically ill Gus is more amenable to intervention.
- 14/03/2017IT'S THE DENDRITES SILLY!Brain could be 10 times more active than scientists thoughtwww.cbsnews.com Research from UCLA could challenge scientists’ conception of how the brain...
Comments14/03/2017 #3 Gerald Hecht#2 @Devesh 🐝 Bhatt Exactly! It always has been; funny (but true) s tory...shortly after Albert Einstein moved to Princeton, he was at a party; and after having "a few too many"... he remarked that several members of the administration seemed to be people who "only used 10% of their brains."
Because it was Einstein who said it...many people (fellow professors!!!) assumed that it was true and that he was being serious, LOL.
Anyway that is the actual origin of that saying...I can't tell you how many Psychology Professors and Neuroscience Professors have ACTUALLY TAUGHT THAT IN CLASS (and believed it)...a whole generation or three of "educated people" have grown up...actually believing this to be a "primary rule" in PSYCHOLOGY/NEUROSCIENCE!!!
It's always been known by serious scientists to be untrue (just think of REM sleep as one piece of evidence)...any electrophysiologist working in the CNS knows that we ALWAYS use ALL of our brain...ALL OF THE TIME...
These "new' details about the dynamics of dendritic "resting potential fluctuations" just helps to explain a little bit more about the mechanism...gets closer the quantum world of subatomic particle physics.
Pretty cool stuff!!
- 13/03/2017Clinical Trial For Cerebral Aneurysm Appears To Still Be OpenSafety and Efficacy Study of Etanercept for Aneurysmal Subarachnoid Hemorrhage - Full Text View - ClinicalTrials.govclinicaltrials.gov
- 13/03/2017APPEARS TO STILL BE RECRUITING PARTICIPANTS FOR CLINICAL INTERVENTION OF CEREBRAL ANEURYSM:
--Another Type of Paradigm Shiftwww.bebee.com Traditionally, students have been introduced to the study of Pharmacology by dividing the subject into two broad subfields; 1) Pharmacokinetics :...
- 04/03/2017Break Glass OBLY in Case of Emergency!Dr. Gerald S. Hechtpsiwebsubr.org
- 04/03/2017You guessed it --another "RES IPSA LOQUITUR!"Big Pharma Quietly Enlists Leading Professors to Justify $1,000-Per-Day Drugswww.propublica.org As it readies for battle with President Trump over drug prices, the pharmaceutical industry is deploying economists and health care experts from the nation’s top universities. In scholarly articles, blogs and conferences, they lend their prestige to...
- 03/03/2017RES IPSA LOQUITUR!Medicinal plants - Wikipediaen.m.wikipedia.org
- 02/03/2017Ketamine Eases Severe Depression, But Questions of Dosage and Duration Remainwp.me Summary: A new study reports research into the term of use of ketamine to treat depression is limited.Source: Yale.Recent studies have confirmed observations made by Yale clinicians decades...
- 27/02/2017What Is Perispinal Administration?Another Kind OF Paradigm Shiftplus.google.com Another Kind OF Paradigm Shift - Gerald Hecht -...
- Producer25/02/2017Buzzing with emotionThis article has been updated with the insertion of instructional video clips. This may enhance the value of the subject specifically as regards psychotherapists, coaches and those interested in the current understanding of the mind-body...
Comments26/03/2017 #20 Savvy RajAppreciate your field of work on the neuromodulators as well the insights @Ian Weinberg and thank you for providing some clarity on a very challenging subject. Mental health issues are certainly tough on the sufferer and their support system like their family and friends. Your post is informative and interesting as well. Kudos for creating such a succint awareness of the dance of opposition in the inverse interplay of these emotion centers.26/03/2017 #18 Gerald Hechthey @Ian Weinberg , have you noticed how many botanical sources of naturally occurring MAO-B selective Inhibitors there are; and how many of them also have anti pro-inflammatory cytokine activity as well? I wonder if its a coincidence that even the "laboratory/kitchen made" ones also do the 5-HT2c/empathogen thingie? I wonder if its a coincidence that the substituted phenylethlamine "DOI" is not only the most potent TNF-alpha inhibitor known to humankind...but also provides a long "day at the beach trip", was first synthesized and documented by Sasha (Shulgin)...and how long and "zany/happy" --the lives of folks like Sasha and Albert Hoffman are best characterized as...
...personally, I prefer "zany/happy/whacky/silly" to umm... whatever the opposite of that is...and also prolly explains why its taking me so long to get into one coherent book (I don't want it to be non-linear/heavily annotated in the David Foster Wallace sense --cause there is no need for that with the "mainstreaming" of what we used to call hypertext...
...its more the case that actually writing it is less fun than doing it, lol.
I should listen to my inner @Phil Friedman and "measure twice, cut once"...actually, I guess that's what I'm doing...Mahalo!26/03/2017 #15 Sara JacoboviciGrateful for the tag @Ian Weinberg. Love your work and I find that you're a great communicator; both written and as a speaker (plus, I appreciate your sense of humour). "The quietening of the amygdala", great title for a future work. You write, "Unfortunately for us, the amygdala is in turn stimulated by the very chemicals that it secretes." For me, this is a reminder that the strides we have made in looking at our brain is great, but at the same time, we are still at the mercy of its mysteries. Looking forward to future posts.26/03/2017 #14 CityVP 🐝 ManjitPrior to reading this I would be clueless if someone had said "Nucleus Accumbens". This is nothing like the social press that the Amygdala has received and perhaps I don't know it because nucleus accumbens isn't something that jumps of the page, but I can for sure see the relationship between the two now and it makes me wonder how these part of the brain triggered each other in the brain of David Foster Wallace - a great writer who succumbed to the malady of depression.
I will follow up more on this part of the brain, thank you for elevating my understanding Ian.
http://www.neuroscientificallychallenged.com/blog/2014/6/11/know-your-brain-nucleus-accumbens26/03/2017 #13 Joyce 🐝 BowenVery interesting. I have never been able to take SSRIs, always suspecting my dopamine and norephinerinwhatcahwhosit levels needed to be played with. There are, however, few medications that I found to do this. Now that I'm aging, side effects are critical. I experience quick and severe elevations in blood pressure, so there are many medications I can't take. Gabapentin has been successful in alleviating what I'll call the 'trapped animal' syndrome.
Of course, I am just an amateur. You provide a wonderful path to understanding some of it.26/02/2017 #10 Ian Weinberg#6 Apologies @Pamela 🐝 Williams I seem to have digressed and missed the important point that you raised: Yes absolutely. The presence of your father may well have created a stressed, high cortisol milieu in your pregnant mom which may have sensitized the amygdala of the unborn fetus. The introvertedness which subsequently developed in the child/adult could well reflect a heritage of fear and defensiveness. Thanks again for that shared info.26/02/2017 #7 Gerald HechtVery good post Ian;my original Masters was going to be an expansion on the idea that the overwhelming etiology for depression that starts to become persistent...would "show itself" in the form of dopaminergic anomolies in the 📉 direction, along with increased pro inflammatory cytokines--usually "exploding into a "autocannabalistic storm"...you can probably see that in my current "neurowork"...
...at the time, my committee members told me that my "hypo-dopamine/anhedonia hypothesis" was "ridiculous"...and nothing more than a false hypothesis based on Olds and Millner's 1950's preclinical work with rats doing "stupid pet gricks to electrically stimulate the medial forebrain bundle. I even wrote to Arvid Carlsson in (yes) Sweden...
....his enthusiastic reply didn't even help.
I ended up looking at the "neutral pathways differentiating thermal perception" --very interesting functional neuroanatomy and tricky neurosurgery; but ultimately, only satisfying to me...when I GOT A DOPAMINE RELEASE from not botching it! REFERENCE 17 in this: http://www.nature.com/neuro/journal/v17/n11/abs/nn.3828.html
Wow...(yawn...lol)26/02/2017 #6 Pamela 🐝 Williams#5 My train of thought from my story was; the emotional and physical abuse my mother suffered when he was home regularly and the impact it might have had on the child she carried at the time. That's what came to mind from your statement:
"Raised cortisol in pregnant women crosses the placenta and compromises pre-frontal cortical neuron maturation and subsequent IQ of the newborn. It also sensitizes the amygdalae of the unborn child giving rise to the birth of fearful infants (compromised EQ)"26/02/2017 #5 Ian Weinberg#3 Thanks for sharing that @Pamela 🐝 Williams Interestingly, I didn't even go into the subject of epigenetics. In epigenetics research it's been shown that the lifestyle and habits of an individual can alter what the DNA expresses and suppresses. The big rub of course is that the altered DNA is passed on to the progeny. It is therefore of great significance that in a study published last week, it was shown that the sons (but not daughters!) of cocaine-addicted fathers, have poor short term memory! We're only just beginning to scratch the surface of this very important new dimension of neuropsychology.25/02/2017 #3 Pamela 🐝 WilliamsThat was just fascinating Ian! I'm particularly interested in the impact on the unborn. It's a train of thought I've always followed; Coming from a large family, with a father who was in the military and did a lot of time in combat zones, while my mother, his wife was pregnant. I have noticed emotional/personality differences in the seven of us and looking over our history I realized that the times he was home during the pregnancy the personality of the child was more introverted while those carried and born while he was away were more extroverted. (FYI, my biological father was an alcoholic, and a mean one at that) My heart father was my stepfather, a grand man, so don't be feeling sorry for me :-) ...this is just the curiosity part of my brain doing overtime!
- 25/02/2017Hello fellow bees. This morning I created this new video buzz on YouTube. Featuring 30 super-fantastic bees to follow!beBee, Successful Personal Branding. https://www.bebee.com/ Created by Jeremy...
Comments25/02/2017 #54 Liesbeth Leysen, MSc. Brand Ambassador beBee, Inc.@Jeremy 🐝 Krier you are an awesome Bee.25/02/2017 #53 Liesbeth Leysen, MSc. Brand Ambassador beBee, Inc.Oh my God what a beautiful gift thanks so much
- Interesting Article On Cannabis As Opioid Replacement and Withdrawl Therapy.Medical cannabis company to launch opioid-replacement protocol...www.duluthnewstribune.com MINNEAPOLIS — Seeking an alternative to opioid drugs, Vireo Health has released a draft protocol outlining the replacement of oxycodone, morphine and others with medical cannabis for pain treatment.The protocol, called FREDOM — Flexible Reduction...
- Holy Spice Rack Lego Batman!Stupid drug story of the week: The nutmeg scare.www.slate.com Lock up your children! Incinerate the contents of your spice rack! A new drug menace is sweeping the land, and its name is nutmeg! We know this because...
Comments26/02/2017 #3 Devesh 🐝 BhattTrue, nutmeg can be intoxicating unless you mix a bit of fenugreek in it and consume it as a spice in food.
Slowly slowly a person becomes immune to intoxication and achieves the benefits of nutmeg which are many.
It is also part of Indian kitchen practices because some women have got high from the fumes of nutmeg when they forgot to add fenugreek while cooking food.
Women in rural India are more aware :)
- WHOA; DUDE...THIS IS SO OLD; ITS LIKE A DORIAN GREY (GRAY) THINGIE!Information Processing in the Parabrachial Nucleus of the Pons - Springerlink.springer.com
- 24/02/2017Krewe Of Common Sense Arrives At Southern University Ag Center --Possibility That Award Winning Behavioral Neuropharmacologist May Save Louisiana Mardi Gras!
- 24/02/2017Common Sense Arrives In Louisiana!Southern looking for vendors to operate medical marijuana programwww.theadvocate.com The Southern University Agricultural Center could have a medical marijuana program in production by the end of the...
- Producer23/02/2017How Genetics Can Influence BehaviorHow Genetics Can Influence BehaviorThe 1960s served up a tsunami of ideals, and it wasn't just political backlash. The post-war society proposed a revolution against the eugenics of the 1930s, insisting that people's behavior was simply a product of...
- The First Ecologically Valid Animal Model Of Prenatal Cocaine ExposureChanges in progressive ratio responding for intravenous cocaine throughout the reproductive process in female rats (PDF Download Available)www.researchgate.net Official Full-Text Publication: Changes in progressive ratio responding for intravenous cocaine throughout the reproductive process in female rats on ResearchGate, the professional network for...
- Another Kind OF Paradigm Shiftwww.linkedin.com Traditionally, students have been introduced to the study of Pharmacology by dividing the subject into two broad subfields; 1) Pharmacokinetics:...
- New Data regarding e-cigarette use in select college age populationsPerceived risk and benefits of e-cigarette use among college studentswww.sciencedirect.com
- 21/02/2017Are Cyborgs In Our Future? 'Homo Deus' Author Thinks Sogpbnews.org The human species is about to change dramatically. That's the argument Yuval Noah Harari makes in his new book, Homo Deus: A Brief History of...
Comments11/03/2017 #13 Rahel Sivan#5 Dr. Hecht.: Thank you for fulfilling all of my fantasies. Now, armed with some fresh, new ideas, I will NEVER sleep, again.! Lol. I am only half teasing, too. This is the kind of thing I could spend the rest of my life looking into., and NEVER tire of looking. Thanks, again. Don't be surprised if I follow you forever! :)23/02/2017 #12 Gerald Hecht#11 @Phillip Hubbell yeah; I think that what bothers me about some of these newer "thingies"...like the silicon/carbon merge ...and (even more) the application of crispr to make deme edits that become inheritable ("gene drive") is that (unlike the historical endeavor known as eugenics) for the first time in human history --socioeconomic disparities can (will) very quickly turn into a true "bloodline/breeding type, permanent, biological caste system."
The previous notions of that type of thing...were silly, and based on false assumptions --this isn't.23/02/2017 #11 Phillip HubbellBack in the dark ages, at the beginning of fax machines, protocol converters and basic data communications, we used to joke about how we had invented all this technology to give ourselves more leisure time but used the technology to order in sandwiches so we could work at our desks. Soon we will be sending the cyborgs out for sandwiches. We should only worry when they stop coming back.23/02/2017 #9 Gerald Hecht#7 @Devesh 🐝 Bhatt I think the safest rejoinder for me to offer up at this time is ...steal Neo's last line from the first "Matrix" (the only one --but that's a different discussion) : "I'm not here to tell you how this will end...I'm here to tell you how will begin...."23/02/2017 #6 Gerald Hecht#3 @Melissa Hefferman oh ...this stuff is WAY PAST THAT...
... IT'S ACTUALLY A VERY GOOD TIME TO BE ABSOLUTELY TERRIFIED!!!
If you are still still curious about (it's already been opened anyway) this PANDORA'S BOX 3.0 --just Google around for things like "CRISPR" + "GERM CELL EDITING + GENE DRIVE.
WARNING ⚠️: Don't do this before bedtime (if you had actually planned on sleeping).23/02/2017 #5 Gerald Hecht#4 @CityVP 🐝 Manjit and wait until desktop crispr cut and paste germ line editing is available for Windows...THE DAY WHEN DESKTOP (EASILY HACKABLE) GENE DRIVES replace METH LABS in mobile homes in a neighborhood near you and near me...Then it's more like the original (1960's) Star Trek episode of "Khan"...
... (although Ricardo Montelban [sic] was awesome in that)23/02/2017 #4 CityVP 🐝 Manjit#3 I am having the Hecht-7000 model transplanted into my brain when I am 80 years old, so for me as a cyborg this will be an improvement.
Unfortunately due to Louisiana being mostly under-water by the time Gerald reaches 80, only the cheaper Manjit-DX100's cyborg brains will be available in his region, so when Gerald gets it he will have to say goodbye to his far superior organic one.
Unfortunately neither of us will be able to afford the Javier-Super7, we can barely afford an i-Phone7 now never mind contemplating that one.