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  1. maria pilar pich pou ,MD
    Technique developed to allow neuron-specific drug delivery to the brain
    Researchers at Duke University and the Howard Hughes Medical Institute report that they have developed a way to deliver drugs to specific types of neurons in the brain, providing the ability to study neurological diseases while also promising a more targeted way to treat them.
    A new method named DART (drugs acutely restricted by tethering) may overcome these limitations. Developed by researchers at Duke University and the Howard Hughes Medical Institute, DART offers the first opportunity to test what happens when a drug is targeted exclusively to one cell type, according to the investigators.
    In its inaugural study, DART reveals how movement difficulties in a mouse model of Parkinson's disease are controlled by the AMPA receptor (AMPAR), which is a synaptic protein that enables neurons to receive fast incoming signals from other neurons in the brain. The results reveal why a recent clinical trial of an AMPAR-blocking drug failed and offer a novel approach to using the pharmaceutical.
    The team's paper ("Deconstructing Behavioral Neuropharmacology with Cellular Specificity") appears in the April 7th issue of Science.
    "This study marks a major milestone in behavioral neuropharmacology," said Michael Tadross, Ph.D., assistant professor of biomedical engineering, who is in the process of moving his laboratory from the HHMI Janelia Research Campus to Duke. "The insights we gained in studying Parkinson's mice were unexpected and could not have been obtained with any previous method."
    DART works by genetically programming a specific cell type to express a type of GPS beacon, known as a HaloTag, which is an enzyme borrowed from bacteria that is inert. It does nothing more than sit on the cell surface. Nothing, that is, until researchers deliver drugs loaded with a special homing device.

    
    maria pilar pich pou ,MD
    Technique Developed to Allow Neuron-Specific Drug Delivery to the Brain | GEN Genetic Engineering & Biotechnology News - Biotech from Bench to Business | GEN
    www.genengnews.com Team publishes study describing a way to deliver drugs to specific types of neurons in the...
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  2. maria pilar pich pou ,MD
    maria pilar pich pou ,MD
    Stanford study suggests tiny portions of the brain fall asleep and wake up constantly
    www.news-medical.net When we are in a deep slumber our brain's activity ebbs and flows in big, obvious waves, like watching a tide of human bodies rise up and sit down around a sports stadium. It's hard to...
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  3. maria pilar pich pou ,MD
    maria pilar pich pou ,MD
    Researchers' sexism fears are putting women's health at risk, scientist claim...
    plus.google.com Researchers' sexism fears are putting women's health at risk, scientist claims  Male and female brains react differently to drugs when it comes to some ... - Neuroscience Roi-Girard -...
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  4. maria pilar pich pou ,MD
    maria pilar pich pou ,MD
    Injectable wires for fixing the brain Novel treatments for neurological disea...
    plus.google.com Injectable wires for fixing the brain Novel treatments for neurological diseases might be possible with a flexible mesh that can prod individual brain c... - Philippe Roi - Tristan Girard -...
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  5. maria pilar pich pou ,MD
    maria pilar pich pou ,MD
    Neurociencia. Música en la ciencia.: ¿Y si no supieras como moverte cuando cierras los ojos?.
    amtoral.blogspot.com.es
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