- Producer07/08/2016Another Type of Paradigm ShiftTraditionally, students have been introduced to the study of Pharmacology by dividing the subject into two broad subfields; 1) Pharmacokinetics: The study of the administration, absorption, metabolism and elimination of drugs from the body, and 2)...
Comments11/01/2017 #37 Lisa VanderburgOkay @Gerald Hecht...you know I'm a slooooooow learner. This is absolutely fascinating (I think)! Just to get it right without pictures, do you mean an interface [of sorts] between para-vascular spaces in the human cerebral cortex - that is your way in? How is that considered non-invasive; not an accusation but you are sweet enough to understand my academic prowess. From that most impenetrable of crossings (unless you're a virus), the BBB with its 400 miles of blood vessels is a bit of a bastard to overcome, no doubt. What about intranasal induction like Prof. Frey....does it stand a chance?
Sorry...lots of q's, like @Deb 🐝 Helfrich. This is a real promise - I applaud you!09/08/2016 #36 Gerald Hecht@Joanna Hofman Let us hope that we can see this thing throug to its full potential; we all have been touched either directly or in the suffering of a loved one; and it needn't continue; the only obstacles are corporate greed, politics, etc. This is to important --as we all know...#3308/08/2016 #30 Gerald Hecht@Deb 🐝 Helfrich There are clues as to potential escapes...biochemically, there is the fact that dopamine itself (ironically, and "teasingly" in the context of the Perispinal administration route) IS a neurotransmitter, which, in the periphery, CANNOT CROSS THE BLOOD-BRAIN-BARRIER...most of the "discussion" regarding this consists of avoiding the full discussion and starting another --on the role of peripheral dopamine as a QUITE SPECIFIC regulator of Renal Blood Pressure...whereas the functionality equivalent catecholamines elsewhere in the peripheral circulatory system are epinephrine (adrenaline) and norepinephrine (noradrenaline). To me, although this is so vague and intuition based as to barely qualify as a hunch...perhaps; there is some sort of (stem cell commonality?) between cells comprising portions of the kidney, and dopaminergic producing neurons in at least one of the 4 dopaminergic circuits in the CNS. We know that the dopamine in the periphery cannot enter the brain. We know that both the brain and periphery contain dopamine. To me that is "strange" --it "feels" like the disconnect there shouldn't just be left "dangling" --dismissed with a shrug (as tonsils and the appendix once were). This could be worth further exploration (in fact, it now seems to have captured my attention). #2408/08/2016 #24 Deb 🐝 Helfrich#20 He has been proving it - the substania nigra is likely effect, not cause, maybe only one of them. He can get native dopamine functioning via exercise, but then ingesting a pill causes overload into dyskinesia or even shutdown. We were just talking yesterday that I wish we had a picture of his sn from January and could compare it to one today, I'd put money that there would be a lot more functioning cells. But then he has to take a pill and those functioning cells, say, well, ok, maybe you don't want us back in production.... vicious cycle.08/08/2016 #20 Gerald Hecht#18 @Deb 🐝 Helfrich @Gary Sharpe this I am still thinking on...it's becoming closer to inescapable that the dopaminergic depletion in the substantia nigra; is (not a red herring)...but not an etiology... I'm going to read @Ali Anani piece first, while I can, before school carpool, but --don't you think that just as an X-Ray can lead to a physician saying: "fractured tibia"...it can't lead them to say: "you fell out of a tree two hours ago at your friend John's house on 3rd Street and landed with your tibia at an angle of X degrees from vertical"... I think the range of conditions which Perispinal etanercept can treat is a big clue that a loss of pigmentation in the sn is telling us what the X-Ray can. It's not telling us what the X-Ray can't. The analogy was rushed; its clothes far from tailored...still; more soon.
- Producer11/01/2017Family and what they teach usMy dad has Parkinson's Disease. My dad's legs don't work so well and he is supposed to use a walker, he doesn't and at times it feels as though the roles have reversed. I get why though. As a contractor my dad was a power horse. His own boss...
Comments11/01/2017 #12 Max🐝 J. Carter#10 @David Navarro López it appears to me you honor him daily in the way you live.
I love the tile concept you shared with us and thank you for doing so.
It reminds o the old line "The older I got, the smarter my father got."
I agree I think our dads would have been great friends and I appreciate the friendship that you and I have been building slowly over time.11/01/2017 #10 AnonymousIn Spain we use to make tiles with sayings or adages on it and hang them in the wall like this https://3.bp.blogspot.com/-MSbo-Mp78GA/Vy-PV9PFdlI/AAAAAAAAUBo/VNsdi7Z3EoE0FsV-2oYuackN6vsKY4mqwCLcB/s1600/azulejos%2Bcon%2Brefranes.jpg View moreIn Spain we use to make tiles with sayings or adages on it and hang them in the wall like this https://3.bp.blogspot.com/-MSbo-Mp78GA/Vy-PV9PFdlI/AAAAAAAAUBo/VNsdi7Z3EoE0FsV-2oYuackN6vsKY4mqwCLcB/s1600/azulejos%2Bcon%2Brefranes.jpg
I remember a very good one, which I am translating for you:
At 5 years old, Papa knows everything
At 15, there are things Papa doesn't know
At 25, Papa knows nothing
At 35, maybe Papa was right in something
At 45, I am going to ask Papa
At 55, I wish I had my Papa
My Father passed away on 2008 and there is no single day my mind flies to him.
I was lucky to have him, learned a lot from him. He never was too tired to teach me something. Whenever something had to be done at home, fixing a door, painting, whatever, he always took me with him and made me help him, explaining me why and how he was doing it, letting me do it, even if wrong, to learn.
In many ways, when you described yours, it made me think of mine. I am sure they would have been good friends.
I believe we both have been fortunate with our respective fathers.
I saw him going down in his health, day by day. However, he never left his spirit going down.
I hope I will honour him. Close11/01/2017 #6 Max🐝 J. Carter#3 It felt like a living eulogy as I was writing it. Kind of preparing myself in away for the inevitable.
I found with my dad that there was this unspoken competition for alpha dominance so to speak that went on for too many years. It has done both of us a world of good to set that aside and work it out. I think a lot of fathers and sons go through it and I see it in mothers and daughters at times
I remember the old movie THE BREAKFAST CLUB and that I am calling it an old movie is making me feel old ;)
When a teen girl is asked why she wants to run away she says "My home life is unsatisfying."
The response summed up was so is everyone else's or we would live with our parents for ever. I only hope to not have the same rfit with my own son and work at it with him. He's 12.
Thank you @Lisa Vanderburg for your kind words, they are felt and appreciated.11/01/2017 #4 Julio Angel Lopez LopezI'm doing it @Max🐝 J. Carter
He is 90 on the 17th of this month.
I have the impression that his gaze is lost in memories and I hear his stories repeated over and over again, giving him a face of surprise and laughter as if he told me for the first time.
I own him.
Thanks11/01/2017 #3 Lisa VanderburgWow...that hit home, Max. What you have so beautifully written is a living eulogy, although I can understand if you don't see it as such!
I feel your steps, moments of watching, waiting and breath-holding regarding your father's Parkinson's - my husband is 18 years into his and is moving to a wheelchair (temporarily, of course!). You are a good son and a practised listened; your father has taught you so many great life-lessons, and I find it so freeing to hear you talk of this - even though it costs you plenty! My husband started aged 49, so our sons were early teens. They never talk about it (at least to me). I wish they did.
Thanks @Max🐝 J. Carter, for the love you have for your father.
- Producer10/01/2017Ode to January and another new year, dagnabit.It is January. This is the time when there is no yesterday, there is no tomorrow, there’s only the now. It carries the awful threat of staying that way; I empathise with our ancestors who waited in the dark with fearful longing to see if the sun...
- 31/12/2016Hacia una muela inteligente para luchar contra el párkinsonesmateria.com Un sensor que detecta los síntomas del párkinson y un diente artificial capaz de liberar fármaco constituyen el "proyecto más prometedor" de la UE para mejorar la calidad de vida de los...
- 15/12/2016@Gerald Hecht - I would really appreciate it if you could offer some of your professional insights on this development and the new drug MSDC-0160, and perhaps help me translate what the drug does into some nutritional interventions for @Gary Sharpe to consider.
http://www.msdrx.com/pipeline/msdc-0160New hope for Parkinson’s disease - VAIwww.vai.org For the estimated seven to 10 million people living with Parkinson’s disease, there’s new reason for...
- 10/12/2016CANNABIS STOPS Parkinson's Disease Symptoms CANNABIS is a MIRACLE PLANT from Mother Nature !! Watch Medical Marijuana's effect on Parkinson's, Part 3 of 3. Aided by a fellow Parkinson's patient and...
- 10/12/2016Man With Parkinson's Disease Demonstrates The Relief He Gets From Medical Marijuana! Man With Parkinson's Disease, Can we get 1000 likes? Here's a link to my smoking videos https://www.youtube.com/watch?v=6FuadaVXjc8...
- Producer22/04/2016How To Get Moving Again with Parkinson's DiseaseAt the core of the concepts behind Out-Thinking Parkinson's is the understanding that the pathways to movement in the brain are manyfold and hence that, with the aid of the right diet and supplements together with the optimal environment and...
- Producer15/11/2016Love hurtsIt's Care-giver month again....think I'll have a nap. Don't get me wrong - for other carers, I care. I'm sure they do a stellar job and remain blissful, serene and contented. Well done!Alas, I'm the other type: bemused, confused and cranky with it!...
Comments16/11/2016 #14 Cyndi wilkins#7 The wave hit hard...an ocean of emotion...I'm still picking the seaweed out of my hair...But I'm getting there;-) Yeah, that whole sickness and in health thing isn't all it's cracked up to be...Don't get me wrong...I love, honor and respect the kind of love that it takes to be a care giver...But sometimes it hurts like hell...experiences like this will awaken that sleeping dragon in anyone...I suppose if it were easy, there would be no lesson in it...We are all our own greatest teachers...sending you LOVE:-)16/11/2016 #11 Lisa Vanderburg#10 I hear you, @Irene Hackett! It seems wimmin are bent to this role; God love the male care-givers, but they are a rarer breed....must be the anticipation thing; we corral wobbling toddlers and crashing kids, so it's just an ergonomic problem :) Just for laughs: my father died in 2010 - I had been assisting my step-mother in his care. It was my night - his last. He was his usual cranky self (not in pain, mercifully) and was struggling to get out one side of the bed which was blocked, while I tried to steer him to the other side. He got so mad he had his final event. His last words were, 'oh SHUT UP woman!!'15/11/2016 #8 Lisa Vanderburg#5 You called it dead to rights, @Deb 🐝 Helfrich! It crept up slowly - all this....mayhem. I think I have come to terms with my 'lot'. I have no illusions as to what the future holds, so I set my eyes on the goal: to be in control when the proverbial really hits the fan! After that, I imagine no more - it's not of consequence. That's not a sentimental statement or plan, it's merely the truth! To think my sister (years back) used to believe in reincarnation - ha! I'd say to her, 'who in their right mind would want to come back to this world of pain??' But I could think of less-lived lives!15/11/2016 #7 Lisa Vanderburg#6 Good Lord @Cyndi Wilkins - I am so very sorry for your angst. I can totally empathise when you say, ''The only saving grace for me is that he also suffers dementia and has no memory of what has happened to him...'' You HAD to put him in a nursing home: you had no choice, and I hope you're not still beating yourself up for that. I have the dubious benefit of having to care for my spouse until 'death do us part'. That gives me the onus to be both pit-bull and dragon for him (the upside :) ), and I apologise in advance for those that will feel my wrath should they ignore or neglect my charge! The lines are just too bleary when it's your parent - it warms my heart though; you're clearly mutual love.15/11/2016 #6 Cyndi wilkins"But I’ll tell you what’s exhausting: anticipation. To have to be on full-alert for when he’s going to ‘go’ (potential fall), to know when he’s going to crash into something or other requires a fair amount of following like a guard-dog." Oh dear Lisa....I feel this soooooo profoundly right now...I've been living this nightmare of dragons and demons ever since I found my dad one morning several weeks ago like a turtle on his back in the bath tub...He had a stroke as he was making his way to the bathroom in the night and fallen over...I thank God every day that he was still conscious and not severely injured, however the stroke took it toll...After several weeks of trying desperately to care for him at home I have had to make the heart wrenching decision to put him in a nursing home...The emotional backlash is like being dragged into an undertow and not being able to surface for air...The only saving grace for me is that he also suffers dementia and has no memory of what has happened to him...My heart goes out to you.15/11/2016 #5 Deb 🐝 HelfrichFrom my humble perspective, embodying the dragon, for your own good, is the most sane approach. Get thee to someone who can begin to comprehend. It is isolating trying to explain something that is inexplicable.
And self-care! I see the challenge so clearly. The need for vigilance. But that very vigilance is actually probably part of what created the situation to begin with. It will be reflected back on you at the most poignant of moments. After caring for weeks non-stop, the slightest diversion of focus will result in some sort of catastrophe either physical, or much, much worse, the allegation that insinuates that you have been selfish.
In a very tiny, miniscule way, I can identify the cycle with my puppy days. It wasn't the damage to the objects being chewed so much as the inability to see chewing and swallowing as harmful that ravages the companion's mind, which is walking its own tightrope of sleep depravation. Wondering if there are any puppy-proofing sorts of options in your vastly more complex scenario?
Caring about you from afar!15/11/2016 #3 Lisa Vanderburg#1 Oh, I am touched by your words and your wisdom my friend, @Ali Anani! I am so far from a super-anything, I look at amoebas in awe :)
Life is one long prat-fall; a losing battle with decrepitude. It's the same for everyone - those with chronic disease (especially neurodegenerative) just KNOW they're losing earlier. Borrowing from your pensive and beautiful buzz, Adaptations to Emotional Flooding, I just have a little root-rot!15/11/2016 #1 Ali AnaniI am deeply touched by your buzz @Lisa Vanderburg. Your story is full of anticipation and I understand fully your saying that anticipation makes us edgy. I almost "melted" like an ice cube while reading " I have strong opinions, but clearly more lily-livered about my own set of values, because the lines keep changing or blurring. They didn’t always. If it appears I’m describing a stranger; we’re getting closer"! This is a deep description of many of us and I am not sure I could ever expose my feelings so eloquently and creatively. I wonder how do you make the time to write and comment. You are a super human.
- 07/11/2016Video record of first ever session with "Smovey Rings" part 2.
Next I incorporated these into my dance therapy and walking exercise. I found they greatly assist, as I think the video clearly shows.Smovey Rings and Parkinson's Disease Part 2 Video record of first ever session with "Smovey Rings" part 2. Next I incorporated these into my dance therapy and walking exercise. I found they greatly...
- 10/11/2016Day 3 exercising with [and without] "Smovey" Rings and the day after receiving my second treatment of K.O.R.E therapy from Tessa Donovan. I doubt anyone who has not followed my Journey of Resurrection from 7 years of degeneration into Parkinson's Disease would have a clue about my diagnosis from watching this. Indeed, this is the first time even I cannot see any of the tell tale signs.
I cried when I watched this back with my Mum.Day 3 with Smovey Rings and Parkinson's Disease Day 3 exercising with [and without] "Smovey" Rings and the day after receiving my second treatment of K.O.R.E therapy from Tessa Donovan. I doubt anyone who...
Comments10/11/2016 #1 Charles David UpchurchOutstanding progress, @Gary Sharpe !
I try to keep my comments and my excitement in check as I have seen you break through (or work around) one challenge after another. Sometimes your leaps forward cause me to forget the big picture.
I realize, as you do, that you can't expect every day to be a breakthrough, yet every day you keep hope alive that you will at least maintain most of your progress to date, and--when the time is right--make another step (or leap) forward.
I celebrate your struggle as much as I do your progress. You have given us all a lesson in focus, a lesson in being open to possibilities, a lesson in letting go of anger and pain, and a lesson in courage, friend.
- Producer08/10/2016Yup. It's all about him.....https://www.linkedin.com/today/author/0_0-YtfauRWrgykW1NKuvu6Q?trk=prof-smAnd that's where you can find all my snarky posts about Parkinson's Disease. I'm stepping out (from LI) awhile to test the waters. All you really need to know about me is that...
- 21/09/2016I don't know if Gary shared this here, but all I can say is WOW
This is amazing! Gary is fighting and beating Parkinson's.
Support his efforts here
https://www.amazon.ca/Out-Thinking-Parkinsons-Starting-Gary-Sharpe-ebook/dp/B01FJXOZUS/ref=sr_1_1?ie=UTF8&qid=1474473619&sr=8-1&keywords=out-thinking+parkinsonsWhat You Won't See at the World Parkinson's Congress #wpc2016 Leadership on Parkinson's Disease isn't about talking about it, nor throwing good money after bad at it, nor giving us People with Parkinson's the false...
Comments30/12/2016 #14 Dorothy AnnyMy husband was misdiagnosed with PD in 2000. Very rapid deterioration and many queries eventually led to MSA (Multiple System Atrophy) diagnosis. A horrible, horrible condition robbing people of independence, dignity, movement, speech, continence, ability to swallow and breathe.we didn't know what to do we tried everything possible medically, we were waiting for his death then one day our daughter got back from work with the email of a herbal Dr saying her friend from work told her about a testimony on how Health Herbal Clinic cured her mom from PD and it truely worked, we were desperate and sceptical but my daughter told me we got nothing to loose and i decided to give it a try. 4 weeks after he started taking the herb he regained his speech and today my husband is fully rocovered from this deadly disease called PD, this isn't a BS it is real you can also contact Healtth herbal clinic on healthherbalclinic(AT)gmail(DOT)com or website on www(DOT)healthherbalclinic(DOT)weebly(DOT)com23/09/2016 #13 Gerald Hecht#11 @Deb 🐝 Helfrich I don't know --regarding my related runners dystonia (much more limited in scope, I know) and in the continuing WAKE of the flood; I'm always spotting some new dust/dirt thingie which drives me crazy anyway like that last line of stuff that never makes into the dustpan...it quickly starts out as jazz bass and minimal drums with brushes...and really quickly becomes composition/choreography ; the first sweep is the hardest; but ihas a powerful draw if you are open to listening (it's not "medical medical")...but that's gonna happen when our little group finally shows 'em that emotional intelligence is a hindrance to medical progress23/09/2016 #10 Gerald Hecht#9 @Deb 🐝 Helfrich indeed; that darned autonomic nervous system can lull us into forgetfulness: 1) heart and lungs: rhythm section 2) whistling and humming: melody, countermelody, harmony, all kinds of household instruments 🎸 everywhere, glass vessels differently filled, brooms....3) polyrhythmic complexity with arms and legs... before you know it we're all "one person dancing bands"...we never stop composing either; it's a lifelong thang!22/09/2016 #7 Deb 🐝 Helfrich#4 @Jena Ball - we might have some thoughts on collaborating.... play is absolutely crucial in opening up our neuroplasticity and nobody is better at play than kids. One of the things @Gary Sharpe and I have in the hopper over the long term is a book about how kids/grandkids can help PwP's initiate movement with some mirroring - Simon says type games among other techniques.
- 01/09/2016Why There is More to Parkinson's than just Neuro-degenerationniume.com OK, World, here is your proof positive that Parkinson's is not just a "neurodegenerative condition" but that there is much more to it. The research results on walking with the disease which I present in this video I hope will be viewed as quite...
- 26/08/2016Trailer for "Out-Thinking Parkinson's: The Journey", a Film by Gary Sharpe and Deb Helfrich http://www.outthinkingparkinsons.com/downloads/ "Out-Thinking Parkinson’s: The Journey” is a compelling, inspirational and educational film, not only about...
Comments26/08/2016 #6 Deb 🐝 Helfrich#1 Thanks for that pointer, @Dean Owen, I also agree that we need to shorten the trailer. We've got a lot of footage, input from others, including their own video experiments and some interesting hypotheses that will ultimtately. We'd love to get connected with anyone in the documentary business for some mentorship on next steps!26/08/2016 #1 Dean OwenA seriously important video that I hope goes viral. Nicely done Gary. I seriously hope that people will watch the whole video. Such is the weird society that we live in that many will turn off within the first minute. They need to see what happens at 1 min 14 secs, then they will want to watch the rest.
- Producer23/06/2016When someone you love has Parkinson's DiseaseMy grandfather had Parkinson's Disease for as long as I can remember. As I got older it got worse for him, I was still young and I remember laughing along with my cousins when he tried to sip his coffee. He always used a saucer and I can remember...
Comments23/06/2016 #5 Gary Sharpe#4 and I am the living proof of what @Deb 🐝 Helfrich just said. I still have bad days (having one today), but eating enough calories, keeping the blood sugar up and drinking plenty of water is so important when re-starting to move again. The problem with Parkinson's is the signals between body and brain get all messed up so we tend not to "get" that we need fuel or water or oxygen! Thanks @Gerald Hecht - back at you23/06/2016 #4 Deb 🐝 Helfrich@Dave Rynne - what @Gerald Hecht is alluding to is some of his old research on exercise. It is absolutely, positively the case that despite all the signals from the brain to stop moving, that it is important to continually build in a routine of movement. There are a number of levels here. First of all, just succumbing causes degeneration in all the muscles, tendons, etc of the body to become rigid and weak, exacerbating the symptoms. Then there is the oxygenation that occurs when we focus on movement, which doesn't need to be anywhere near what we commonly consider 'exercise'. Finally, movement and keeping busy reduces stress at a biochemical level because stress uses dopamine.
Movement is the Definition of Life and even though all the signals are asking him to stop moving, it is utterly important to continue moving through the stiffness, rigidity, tremors, and tics. This needs to be a conscious daily decision in the arsenal of living with PD and is something that it is crucial for the caregiver to be firmly dedicated to supporting. I would be honored to talk with your mom if she is interested.23/06/2016 #2 Gary SharpeThank you for helping raise awareness and this honest look at the impact of Parkinson's @Dave Rynne. Our resource which @Gerald Hecht mentioned is here www.outthinkingparkinsons.com - I also have created a Parkinson's Hive here on beBee and will share your post there.
- 16/06/2016Cycling for Freezing Gait in Parkinson's Disease A 58-year-old man with a 10-year history of idiopathic Parkinson's disease presented with an incapacitating freezing of gait. However, the patient's ability...
- 01/06/2016I was asked to share this info about a new development to help with tremors, and I am delighted to do so.Fawad Bhattiwww.outthinkingparkinsons.com I hope you are doing well. I really appreciate the work you are doing for Parkinson's community. Sadly, my family had also been affected by Parkinson's disease, so I have been working on trying to make the lives of my family and millions of...
- 27/05/2016Prelude to Parkinson's Diseasewww.linkedin.com Losing Myself: Gary’s Prelude Sometime in 2009 to July 2015 My name is Gary Sharpe. In 2009 (the exact date escapes me) I was diagnosed with Early Onset Parkinson’s Disease. This is the story of how...
In this article I have collected together a number of resources and case studies which demonstrate unequivocally that inevitable decline is simply not true and that there is always the possibility of hope. These then are the stories of our fellow travelers who've already escaped from both Parkinsonism and the falsehoods of the medical diagnosis narratives, or are helping others to do so.
- 19/05/2016Learning to Walk Again with Parkinson's Disease and a Pair of Fitflops People with Parkinson's tend to shuffle when we "walk". We take very small steps, hardly lifting our feet off the floor at all. We often trip over things...
- 14/05/2016The News of the Century About Parkinson'swww.linkedin.com BIG NEWS! This has taken me 4 months of full time effort, knowledge assimilation, building the confidence of my own evidence. This is not something anyone can do overnight - the underlying injury...
- 05/05/2016The Sleeper Awakens.
As I write this it is four months to the day since Deb and I started the Out-Thinking Parkinson's project. Throughout this time, Deb has repeatedly challenged me to answer this question:
"Why do you think you developed Parkinson's?"
Deb's question is not really about the medical reasons for my Parkinson's diagnosis, but seeking the deeper truths of what it actually means to have Parkinson's. Until very recently, I had no answer. But as I've improved my condition, both mental and physical, I'm more able to tune in to what is actually happening in my mind and body when the Parkinson's takes hold. As I've pushed the envelope of my understanding and incorporated more interventions into my own life, tested, tried, self-experimented, it has become clearer to me.
The answer to Deb's question is, for me, a Very Uncomfortable Truth. While I have no idea why my Parkinson's started, what biological or environmental factors caused it, looking back now, I believe I understand why it developed and progressed so quickly....
Read more: http://www.outthinkingparkinsons.com/articles/wakeup