- Entry level
- No Education
- Salary to negotiate
Janssen Research & Development seeks to drive innovation and deliver transformational medicines for the treatment of diseases in six therapeutic areas: neuroscience, cardiovascular diseases and metabolism, infectious diseases, immunology, oncology and pulmonary hypertension. In these areas, Janssen aims to address and solve unmet medical needs through the development of small and large molecules, as well as vaccines. The Janssen campus in Beerse (Belgium) has a unique ecosystem covering the complete drug development life cycle, with all capabilities from basic science to market access on one campus. The integrated environment of our campus gives our people the chance to experience many different aspects of drug development throughout their career. It has a successful track record of over sixty years of drug discovery and development and is one of the most important innovation engines of the Janssen group worldwide.
Developing innovative therapeutics to treat diseases like Alzheimer’s disease, various types of cancers and infectious diseases like Hepatitis B, influenza is our passion. In this endeavor, we are seeking to recruit new talent for the comprehensive analyses of high-dimensional datasets using state-of-the-art data science methods applied to drug discovery programs. The position will be opened on the Beerse campus, which is the flagship R&D center for small molecules within Janssen, investing over 1 billion euros each year in R&D.
We are looking for a highly skilled and motivated computational chemist for the position of PostDoc – Open Force Field, Computational Chemistry, at our Beerse, Belgium site. The position is part of the Open Force Field Consortium, funded by an alliance of pharmaceutical and biotech companies aiming to advance the state of force fields for biomolecular simulation and design through an open collaborative effort. The Open Force Field Initiative is a multi-investigator collaboration that aims to build new, quantitatively accurate molecular mechanics force fields supported by a modern software infrastructure, built on principles of open source, open data, and open science. Collaborating academic laboratories include: Michael K. Gilson (UCSD, La Jolla, CA), John D. Chodera (MSKCC, New York City, NY), Lee-Ping Wang (UCD, Davis, CA), David L. Mobley (UCI, Irvine, CA), or Michael R. Shirts (University of Colorado, Boulder, CO). Janssen is part of this consortium and we seek a skilled PostDoc to contribute to this exciting collaborative project.
Responsibilities of the PostDoc Scientist will include:
Develop and execute clear computational programming strategies contributing to the collaboration.
Work In close collaboration with the external collaborating groups to develop the force field via its different working groups
Test developments of the force field on data originating from Janssen or the public domain
Experience with the theory and practice of atomistic biomolecular simulation using molecular mechanics force fields
Comfortable with the Python programming language
Exposure to modern open source software development practices (GitHub, unit tests, continuous integration)
Good multidisciplinary teamwork and communication skills
Bonus qualifications (nice to have, but not required!):
Experience with force field parameter fitting for small organic molecules
Experience with quantum chemical calculations in general, and psi4 in particular
Experience with high-performance computing clusters and/or cloud computing
Knowledge of organic chemistry
Experience with the open-source GPU-accelerated molecular simulation Python library OpenMM
Experience with probabilistic programming languages (e.g. PyMC, tensorflow.Probability, Pyro) and/or machine learning frameworks like TensorFlow
Experience with cheminformatics or computer-aided drug discovery
Appointment: The position will be for two years.
Open Force Field Initiative: To find out more about the Open Force Field Initiative, visit http://openforcefield.org.
Up to 10% travel may be required
Janssen Pharmaceutica N.V. (7555)
About the company
If you’re thinking about taking your career to a place where you can be seen for the talent you bring to your work, where you’ll have a chance to be the driver of your own career, and where others share your passion for caring and success, then we invite you to explore Johnson & Johnson. BE VITAL in your career and make a unique mark. Join the approximately 129,000 men and women who work within our companies and touch the lives of more than a billion people around the world every day.