Gerald Hecht in beBee in English, Scientists and Research, Medical Researchers Toxicology and Behavioral Neuropharmacology Expert Witness Aug 31, 2016 · 1 min read · 4.9K

CHANGING THE ALZHEIMER'S GAME, PERIOD

CHANGING THE ALZHEIMER'S GAME, PERIOD

Make no mistake, the recently developed protocol known as the perispinal injection administration route of drug delivery is nothing short of a game changer in neurology, allowing for peripheral, non-invasive delivery of such compounds to penetrate the CNS.

The area in which the injection is performed (known as vertebral venous plexus), is a bi-directional system; it can be conceptualized as an interface between the peripheral lymphatic system and the ventricular system in the CNS.

A single injection of etanercept, for example, into the vertebral venous plexus followed by a maneuver (similar to a session in the popular relaxation device known as the inversion chair) called Trendelenburg positioning directs the compound through the choroid plexus and into the ventricles. 

Therefore, this injection, which is subcutaneous and performed peripherally, is non-invasive, most importantly, it has been shown to thwart the “first domino” in a plethora of Neurodegenerative (Dementias stemming from a variety of neurodegenerative conditions including Alzheimer's Disease, Pick’s Disease, Lewy Body Disease), Neurotraumatic (Traumatic Brain Injury [TBI], and the sequelae of repeated TBI incidents such as Chronic Traumatic Encephalopathy or CTE. CTE is a degenerative condition linked to repeated head injuries), and Neuropsychiatric Pathologies (including chronic pain syndrome, neuropathies [including diabetic neuropathy]mood disorders such as Major Depressive Disorder [MDD]) and most recently opioid dependence.

In the CNS, the ventricles intimately communicate with the brain parenchyma. The fact that compounds delivered via this route have been shown to reach neurons in the CNS and exert an effect on neuronal functioning demonstrates/indicates how (PERIPHERAL) administration of a ligand known to be incapable of Blood-Brain-Barrier penetration, generates a signal, which is neuronally communicated throughout the brain parenchyma (CNS)

Perhaps the single most exciting examples of these developments can be found in the amazing research and clinical work by Edward Tobinick, Robert Spengler, Tracey Ignatowski and their colleagues.

http://scholar.google.com/scholar_url?url=http://brainimmune.com/new-evidence-suggests-targeting-neuroinflammation-may-one-key-slowing-alzheimers-disease/&hl=en&sa=X&scisig=AAGBfm2NNHDLEsevYITF4WS86DyX_WybFQ&nossl=1&oi=scholaralrt

Latest September 1st Should be Available

http://mobile.nytimes.com/blogs/well/2016/08/04/arthritis-drug-may-have-benefits-against-alzheimers/

LATEST NY TIMES UPDATES (Thursday, September 1st 2016 9:30 AM EST) on NY Times Discussion on Impact of Perispinal Etanercept Administration on Clinical Course of Alzheimer's Disease.

Confirmation of the research results and clinical outcomes reported by Robert Spengler, Tracey Ignatowski and Edward Tobinick and colleagues showing positive effects on a plethora of Neurodegenerative/Neuroinflammatory conditions.

http://well.blogs.nytimes.com/2016/08/04/arthritis-drug-may-have-benefits-against-alzheimers/?comments#permid=19404509:19497033

New evidence shows properties of etanercept result in significantly reduced rates of Alzheimer's Disease (AD) in Rheumatoid Arthritis (RA) patients compared to every other FDA approved RA treatment.

http://brainimmune.com/new-evidence-suggests-targeting-neuroinflammation-may-one-key-slowing-alzheimers-disease/

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http://scholar.google.com/scholar_url?url=http://brainimmune.com/new-evidence-suggests-targeting-neuroinflammation-may-one-key-slowing-alzheimers-disease/&hl=en&sa=X&scisig=AAGBfm2NNHDLEsevYITF4WS86DyX_WybFQ&nossl=1&oi=scholaralrt



Gerald Hecht, 2016. Unauthorized use and/or duplication of this material without express and written permission from this author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Gerald Hecht with appropriate and specific direction to the original content.


Gerald Hecht Dec 12, 2018 · #64

#60 @Lisa Gallagher Yes, etanercept is the generic name for the TNF-alpha inhibitor Embrel

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Gerald Hecht Dec 12, 2018 · #63

#62 @Dale Masters and @Deb Helfrich In all fairness there are numerous compounds found in relatively common plants with neuroprotective effects. Air Cured tobacco (as opposed to Flue Cured) contains several --and yes nicotine is one of them. It also contains beta harmines, harmalines and related compounds which act as natural MAO-B inhibitors with a shared mechanism of action of the prescription Parkinson's Disease Treatment Selegeline. Interestingly enough, the fruit known as the coffee berry contains numerous neuroprotective compounds as well (the "pit" of that fruit is what is known as a coffee bean and when roasted, ground and allowed to have hot water run through it results in the beverage known as coffee) ; additionally --restricting the present list to a few exemplars, we have: cannabis, ashwagandha, kava. There are more. I will post some links that are explanatory and/or point to peer-reviewed biomedical references:
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https://www.obgproject.com/2018/11/15/the-missing-link-between-coffee-and-neuroprotection-is-it-the-caffeine-or-another-component/

https://examine.com/supplements/ashwagandha/
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Of note --all of these (and the plethora of plants that I have left out for the sake of brevity contain compounds which are powerful TNF-alpha inhibitors.

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Dale Masters Sep 13, 2016 · #62

#12 EXACTLY!!
There is one common chemical KNOWN to have neuroprotective effects (WARNING: The following info is not PC...but it's true.)
It's NICOTINE.
http://www.jimmunol.org/content/182/3/1730.long
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376385/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514124/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644496/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912318/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694786/
...just to start off with (and it's not nicotine that's the addictive substance in tobacco...don't have time to post those links...please remind me.)
I love NCBI. :)

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Lisa Gallagher Sep 13, 2016 · #60

#58 @Gerald Hecht if you posted the photo can you tag me too? I'd love to see it. Is entanercept the same as Enbrel? Oh geez when the brain begins to attack itself, it takes on a life of it's own. I am reading a lot of the comments and I admit there is much I don't understand either @Gerald Hecht. It's sort of scary, 3 neighbors within 2 blocks of me developed Glioblastomas, they all received radiation Tx but it seemed to help for just a short period of time.

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Deb Helfrich Sep 13, 2016 · #59

#58 Well, there are a lot of PR type folks....why not write up something in a press-release-elementary style and let's float it around on the other place and see if someone with a loved one might take up the cause pro bono. Trying cannot hurt. Let me know if I can contribute. The right person, the right motivation, the right skill set, or the right connections. I think that is how these things always work. Never the first time, but when it happens it seems meant to be. Just like a perfect ray of light as the sun drops around to the west.

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Gerald Hecht Sep 13, 2016 · #58

#57 @Deb Helfrich I caught a sunset at Skyler's soccer practice tonight that was the most amazing thing I'd ever seen; I never posted a photo of the sky before; I took it with my phone and posted it; I didn't balance or filter anything except the tears in my eyes...actually there are two; I'll post the second one as well (with the moon)... I'll tag ya...That was about 30 minutes before last comment; but it just made even clearer; big brain, big fangs, big paws, big roots, big fruits... sometimes they don't mean jack sh*t to the boss. In the case of perispinal etanercept we may be allowed to have enough people capable of thinking clearly to get us one more chance to make amends...Everybody's seen someone in their life when the big brain starts attacking itself. Big brains equal big decay curves...this stuff stops it and legs it start fixing itself; which still leaves the question: "What are you gonna do with it this time?"

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Deb Helfrich Sep 13, 2016 · #57

#56 That is one tremendously challenging question. Along with why did we evolve in the first place if we were going to use these fancy brains to be so careless. Maybe we should initiate the first beBee summit on immediate steps to hold corporations responsible for toxic products, by-products, and waste produced.... hey did you see that new-fangled hive with honey on tap? The buzz was friday or saturday? Brilliantly simple. There probably are bacteria, algae, fungi, and insects who could really do a great deal of the clean-up necessary...if we create a sustainable way to utilize them.

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Gerald Hecht Sep 13, 2016 · #56

#53 @Deb Helfrich It's more than dismaying--it's "suigenocide "! It's also gone too far now to rely on the wisdom of nature; really, the wisest thing nature could do is get rid of us; but she also is very compassionate I guess. I'm trying to think of a scenario in which the earth requires the survival of the human species to continue as a biodiverse and really cool place... I'll keep you posted

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