HOW EBOLA KILLS : NOT THE VIRUS
Ebola in West Africa: Health workers ready for action
Filoviruses Ebola, Lassa and Marburg are lethal hemorrhagic fevers. The hemorrhage of Ebola infection is caused by adhesion of viral particles to the endothelial lining of blood vessels via a specialized glycoprotein.
The result being infection of, replication in, and damage to, the endothelial cells. The disease is usually fatal. Like a Trojan Horse Ebola virus enters blood cells by binding to the host cell’s outer membrane and a portion of the host cell membrane then surrounds the virus and pinches off, creating an endosome (membrane bound bubble inside the cell).
The Ebola virus exploits substances within the cell to get deep into the cytoplasm where it can multiply. Cytoplasm is the substance between the cell membrane and the cell center. More than a decade ago, clinicians noted striking similarities between patients with Ebola and those with bacterial sepsis.
Two of them- Dr. David S. Fedson, a retired professor of medicine at the University of Virginia, and Dr. Steven M. Opal, a professor of medicine at Brown University- analyzed several studies that have shown that STATINS reduce viral replication in human diseases. They recommend FDA approved oral immunomodulary STATIN drugs which are directly available that can treat the symptoms of Ebola and cure patients.
Thomas Geisbert, an immunologist at the University of Texas Medical Branch at Galveston says: “when you look at the nitty-gritty details of an Ebola infection, a surprising fact surfaces: The virus isn't what ends up killing you.
It's your own immune system.” The most extreme immune attack is the "cytokine storm." Although many viruses, like bird flu and SARS, can trigger this shock and awe assault, Ebola is probably the best at it. At the end of an Ebola infection, it's the cytokine storm that kills you,” says virologist Christopher Basler, at the Mount Sinai Hospital in New York City.
CYTOKINE STORM IS CHARACTERISTIC OF FATAL EBOLA VIRUS INFECTION
Current thinking is that Ebola causes a cytokine storm by the way it affects dendritic cells. Uncontrolled cell infec