Job description


  • Entry level
  • No Education
  • Salary to negotiate
  • London


A biotech who are at the centre of the Cell & Gene Therapy sector whose mission is to drive its growth by collaborating with academia & industry, they provide the expertise needed to commercialise these life changing therapies. They are seeking a Biomarker Discovery Scientist to continue the expansion of their emerging Biomarker discovery team to increase its capabilities. This role will be based at their state-of-the-art Central London R&D laboratories where their Industrialisation group is housed that offers the capabilities to take a therapy from discovery to the clinic.

The Role of Biomarker Discovery Scientist:

This opportunity is within the emerging Biomarker Discovery team to add further expertise to increase the size and capabilities of the team. To play a central role in the application of metabolomics and / proteomics to identify biomarkers to speed up the development of cell & gene therapy products.

Responsibilities includes:

Support the development of an LC – MS Platform
Develop Libraries to enable the discovery of metabolomic and proteomic biomarkers
Develop & validate Mass Spec assays e.g. prognostic and diagnostic assays in a range of biological matrices
Apply ‘omics expertise of datasets to charaterise and optimise cell culture processes
Lead R&D projects in the laboratory, interacting with external stakeholders and colleagues from other teams such as Analytical or Process Development
Contribute to the development of protocols for validation and qualification activities
Present reports and results to internal colleagues and external collaborators.
Mentor more junior laboratory based colleagues

Required Skills and Expertise:

A PhD with emphasis on proteomics or proteomics / MSc with experience in a cell therapy or related environment with metabolomics and / or proteomics experience
Experience in the design and running of LC – MS studies to identify protein or metabolite biomarkers
Proficient in the use of mass spec and data analysis software such as MATLAB, R, JMP etc.
Background in analytical Biochemistry including mass spec applications for metabolomics and proteomics
Experience of method development, validation and the troubleshooting of assays
Background in the analysis of omics based datasets
Experience of chromatographic separation e.g. LC, ion exchange, and characterisation by MS or MS / MS.

Company Overview:

The company’s aim is to advance the cell & gene therapy sector to make the UK the place to commercialise these life changing therapies. They have the capabilities to take a therapy from the discovery phases, across the translational gap to the clinic and then through clinical trials to launch. Using their R&D expertise to achieve this along with their drive for innovation and continuously adopting the latest and most effective approaches. To complement their R&D efforts they have world class clinical operations, regulatory, health economics and market access expertise. Added to this they have developed a unique and highly successful GMP manufacturing facility based in Stevenage where collaborators can manufacture their therapies for clinical trial and commercial use.

They have a strong culture that is focused on collaborative and innovative working to deliver these life changing therapies to patients. As a company they offer excellent career development opportunities through their L&D programme that not only gives you the skills to advance your career but creates opportunities to take the step forwards to utilise them in a new position. Added to this they are continuing to expand as the demand for their expertise increases and they explore new areas of the sector

About the company


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