- Entry level
- No Education
- Salary to negotiate
GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform to deliver strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.
Are you interested in working on some of the most pioneering research platforms in the world of Research and Development? We are currently seeking a highly-motivated Senior Scientist to join our game changing Cell & Gene Therapy research department.
The CGT platform unit is an integrated discovery-development-supply unit which will ensure that ground-breaking CGT medicines are seamlessly and expertly discovered and manufactured for clinical development and beyond. In recent years GSK has been working with a leading academic group in Italy (TIGET) to develop ex vivo gene therapies for Rare Diseases. We now have three ex vivo gene therapy products in late stage development. More recently GSK has secured a significant collaboration in the T-cell immunotherapy field with Adaptimmune and other licensing/partnership opportunities are being pursued. The progression of our own portfolio together with the maturation of emerging gene therapy technologies creates an imperative for GSK to now increase our investment in this space and establish an end to end leading platform. This will enable delivery of the portfolio in Oncology as well as ensuring that GSK is able to capture the potential of the emerging technologies in other therapeutic areas.
The Cell & Gene Therapy Discovery Research team engages with all GSK therapy areas, including oncology and immuno-inflammatory, to develop their pre-clinical portfolio from target to clinical candidates. The focus of this team is to design the transgenes for optimal performance and perform pre-clinical in vitro and in vivo testing to understand how the payload interacts with the biology at the cell, tissue and organisms level. The level of input into the design, engineering and characterisation of candidate assets ranges from fully resourced program teams, to engagement with 3rd parties (e.g. Adaptimmune’s lead NY-ESO-1 partnered project with GSK) and other support functions. Another important mission of the Cell and Gene Therapy Discovery Research team is to identify, incubate and develop novel technologies to enable or accelerate the discovery of future Cell and Gene Therapy medicines. These next generation technologies may come either from within GSK, or from the wider R&D community
There is an immediate opportunity for bright, enthusiastic scientist within the group to support the developing engineered T-cell platform. The Cell Biologist will report into the Discovery Biology Group within CGT Discovery Research. The Discovery Biology group comprises a team of cell biologist and immunologists focussed on the biological development of Cell and Gene Therapy medicines. The team is responsible for the delivery of the early biology package, for targets defined by the Therapy Area, from target validation though to selection of candidate molecules to enable clinical and CMC development. The group works in close collaboration with the Transgene Discovery, Transgene Delivery and Translational Research lines within Cell and Gene Therapy Discovery Research and with the Cell and Gene Therapy process development groups to progress lead assets to the clinic
The preferred candidate will work across multiple programs, primarily those developing engineered T cells and other immune cells. Your focus will be in the laboratory. You will have a strong desire to be involved in cell and gene therapy discovery projects and a willingness to develop and train others as required. You will also have responsibilities for the appropriate maintenance of laboratory equipment and the day-to-day functioning of the laboratory: this will include participation in the routine cleaning of equipment, adherence to lab safety procedures and contribution to the ordering and receiving of laboratory stocks and reagents.
You will have a keen interest in cutting-edge research with a strong desire to deliver science from the bench. The ability to innovate and form productive interactions with scientists across GSK will be key skills for success in this role. Working as part of a multidisciplinary team, the candidate will be responsible for data preparation, analysis, documenting and
About the company
We are a science-led global healthcare company that researches and develops a broad range of innovative products in three primary areas of pharmaceuticals, vaccines and consumer healthcare.
As one of the few healthcare companies researching both medicines and vaccines for the World Health Organization’s three priority diseases – HIV/AIDS, tuberculosis and malaria, we are very proud to have developed some of the leading global medicines in these fields.
Our product portfolio also includes a range of consumer brands, many of which are household names around the world, including Sensodyne, Aquafresh, Horlicks, Panadol and Tums.