Job description


  • Entry level
  • No Education
  • Salary to negotiate
  • Frederick


Cryo-Electron Microscopist

Job ID: req1039
Facility: Frederick: ATRF
Location: 8560 Progress Dr, Frederick, MD 21701 USA

The Frederick National Laboratory is dedicated to improving human health through discovery and innovation in the biomedical sciences, focusing on cancer, AIDS, and emerging infectious diseases.

Position Overview:


The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.


- Independently image samples on the FEI Titan Krios with direct detectors
- Interact with users to ensure the setup of data collections is according to project needs
- Develop workflows for efficient and high-end data collection
- Image samples on the Titan Krios with phase plate and direct detectors
- Service and maintain Titan Krios microscopes at highest performance levels
- Provide scientific and technical advice to investigators on sample preparation, experimental design, data analysis
- Provide guidance on new scientific directions that could have an impact on improving the services provided by the facility


- Possession of a PHD from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for US equivalency
- Hands-on experience in cryo-EM and transmission electron microscopy
- Able to prepare detailed, concise technical reports, including assisting with publications
- Strong laboratory skills
- Must be able to obtain and maintain a security clearance


- Direct experience with all aspects of electron microscope operation
- Experience with cryo-EM specimen preparation techniques
- Knowledge of computational aspects of Cryo-EM
- Must be detail-oriented and able to manage multiple projects simultaneously
- Able to work dynamically in a diverse team environment


- This position is subject to working with radioactive material and requires to become an approved radiation worker

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

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