Job description


  • Entry level
  • No Education
  • Salary to negotiate
  • South San Francisco



South San Francisco
California, United States of America

Job ID: 201902-106439

The Position

The Preclinical Translational PKPD Department at Genentech, Inc. is seeking a Quantitative Systems Pharmacology Modeling & Simulation Intern who is driven to enhance drug development through mechanistic modeling of biological systems. The Translational and Systems Pharmacology Group at Genentech was initiated in 2012 to lead both (1) preclinical & translational PKPD modeling of biologic therapeutics, and (2) systems modeling to support all stages of research and development across molecule types/formats.  Our group is comprised of scientists with PhDs in engineering and pharmaceutical scientists with expertise across mechanistic modeling and simulation, computational algorithm and tool development, and translating complex biology into mathematical models. We work closely with collaborators across all disciplines in therapeutic areas such as oncology and cancer immunotherapy, immune and inflammatory disorders, ocular disease, neurological disorders, and more. Communication and collaboration skills are thus critical skills. The group has a significant external presence, with a growing list of publications in highly regarded journals in the field, numerous oral presentations, academic seminars, and workshop leadership. Our members are leaders of various interest groups, conference programming committees, and working groups in the field of pharmaceutical modeling and simulation. In addition to our application of systems modeling approaches in support of drug development, we are also committed to the development of new technical approaches, algorithms, and tools to advance the field.


 The Intern will be responsible for developing and applying models of complex systems such as tissue and cell dynamics and intracellular signaling in various therapeutic areas including immune & inflammatory disease, oncology, and other disease areas. The successful candidate will have responsibilities for customizing QSP Immunogenicity Model developed by Certara consortium for Genentech internal applications.  These internal applications include modeling in-house in-vitro assays for immunogenicity, identify workflow for translation of in-vitro findings to the clinical model and execute end to end model workflow from in-vitro data to clinical predictions for a test compound.  An additional component will be the presentation of results at cross-functional teams, and department meetings. 


Current or recently graduated Ph.D in chemical, biomedical, or other relevant engineering fields, pharmaceutical sciences, or a related discipline. Candidates will have will have a proven track record and publications applying systems modeling and simulation approaches to biological systems. Proficiency with systems modeling approaches such as differential equation, logic, stochastic, agent-based, or other advanced mechanistic modeling approaches is essential, as is experience with relevant software or programming languages (e.g., Simbiology, MATLAB, R, or C). Experience with modeling and simulation of large molecule PKPD is valuable but not required, as is familiarity with the biology of one or more disease areas. The candidate must have excellent communication skills and the ability to work independently and effectively on interdepartmental project teams to plan, organize, assess and perform model-based analyses. Leadership skills are highly desirable.


Who We Are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

The next step is yours. To apply today, click on the "Apply online" button.

Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity,

About the company

Genentech is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions. We are among the world's leading biotech companies, with multiple products on the market and a promising development pipeline.

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