Job description


  • Entry level
  • No Education
  • Salary to negotiate
  • Santa Clara


Performs research and support development in collaboration with others on projects involving DNA library construction, characterization, and purification.  Participates in activities such as oligonucleotide characterization, enzymatic manipulation of DNA, DNA amplification, genomic DNA library prep, DNA sequencing, polymerase chain reaction, and other standard Molecular Biology techniques.  Assist in probe/primer designs, generation, and hybridization. Also prepares technical reports, summaries, protocols, and quantitative analyses.
You are interested in technology development and DNA measurements. You enjoy wet-lab work and have grasp of the chemistry involved in common Molecular Biology techniques. You are extremely curious about how DNA molecules interact with other molecules and the environment. You are meticulously detail-orientated, systematic, and can think quantitatively. You work cooperatively and openly with senior and junior staff on the team. You are flexible, eager to learn, and can effectively respond to fast-paced environment and changing priorities. You are able to joggle multiple investigations simultaneously. You naturally think about DNA in context of measurements and technology more than biology. You enjoy working with engineers and analysts to enable a new single-molecule DNA sequencer.
Achieve tasks both independently or as part of the team, depending on project scope and needs.
Obtain understanding of project goal. Design and execute experiments that address project goal. Experiments can involve wet-lab work and/or data analysis. Integrate previous and current results to determine next experimental steps and the impact of long-range project goals.
Design and characterize conventional and novel DNA libraries using both qualitative and quantitative methods, utilizing established and innovative procedures. Apply scientific knowledge and accumulated experience to complete projects.
Support internal customers by responding to their needs, which entails bridging engineering, data analysis, and diagnostic applications. Serves as a resource to other departments and research groups. Provides timely response and follow-ups. Assist others in areas such as sample preparation, sample characterization, troubleshooting, and providing solutions,
Accurately and consistently records experimental methods, materials and results in electronic laboratory notebooks. Analyzes data, evaluates results, forms conclusions and implements/documents process improvements.
Presents findings at group or departmental meetings. Applies advanced technical writing skills to produce reports and documents. May assist in preparing summaries, memos, internal reports, presentations, manuscripts, etc.
May or may not have supervisory responsibility; provides guidance to new team members and leads internal/external teams and builds professional relationships.
MS. or Ph.D. in Chemistry, Microbiology, Biochemistry, Bioengineering, Molecular biology, or related fields with 3+ years of hands-on wet-lab experience working with DNA in academic or industry setting.         
Technical expertise in DNA/RNA manipulation, purification, enzymatic reactions, PCR, qPCR, and NGS library prep.
Candidate must have experience in design, characterization, troubleshooting, and analysis of experiments involving DNA beyond ready-made commercial kits or company SOPs.
Ability to design, execute, and analyze experiments to address needs determined by the group.
Detailed-oriented, analytical and systematic in problem-solving and trouble-shooting.
Basic understanding of molecular interaction thermodynamic concepts.
Experience with PCR primer design, BLAST, and ability to use primer design tools.
Ability to work well in teams and across disciplines with complex systems.
Excellent written and oral communication skills
The candidate needs to be passionate and self-motivated with a strong desire to acquire on-the-job training          
Preferred Qualifications:
Experience with NGS data workflow and analysis       
Design, execute, and analysis of experiments using PCR, qPCR, or dPCR
Hands-on experience with running NGS sequencer
Knowledge in Python and/or R
Understanding of bioinformatics and genomics nomenclature and concepts
Understanding of nucleic acids structural biology
Experience working with single molecule technologies.
Experience mentoring junior scientist.

About the company

Roche is a Swiss global health-care company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has bearer shares listed on the SIX Swiss Exchange.

The company headquarters are located in Basel and the company has many pharmaceutical and diagnostic sites around the world – including: Tucson, AZ; Pleasanton, CA; Vacaville, California, Oceanside, California, Branchburg, NJ; Indianapolis, Indiana; Florence, South Carolina; and Ponce, Puerto Rico in the US; Welwyn Garden City and Burgess Hill in the UK; Clarecastle in Ireland; Mannheim and Penzberg in Germany; Mississauga and Laval in Canada; Shanghai in China; Mumbai & Hyderabad in India; São Paulo and Rio de Janeiro, Brazil; Segrate, Milan in Italy; Johannesburg in South Africa; Karachi, Islamabad and Lahore in Pakistan. There are 26 manufacturing sites worldwide.

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